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                                                       OZONE   THERAPY

 

MECHANISMS OF OZONE THERAPY :-

1.  Many ds are caused by oxygen deficiency in body.  Malignant cells are anaerobic & prosper when tissue

    oxygen levels are low.  Ozone restores proper oxygen balance & produces free radicals that selectively

    attack cancer cells.

2.  Ozone decomposes to give hydrogen peroxide, superoxide & hydroxy radicals which can take part

    in secondary reactions.

3.  Strong oxidizer to stimulate increase of cellular anti-oxidant enzymes & inhibit oxidative stress.

4.  Acts as bioregulators to activate several biological functions.

5.  Promotes oxidative preconditioning & prevents damages mediated by free radicals.  Upregulates intracellular

    anti-oxidant enzymes -à inhibits the constant, life-long oxidative stress responsible for degererative ds & aging.

 

USES OF OZONE THERAPY:-

1.        Inhibits growth & kills tumor cells

2.        Enhances immunological processes.  Ozone activates monocytes & lymphocytes & induces production

       of cytokines such as interleukin-1,2 and 6, interferon B and gamma, granulocyte-macrophage colony stimulating

       factor, tumor-necrosis factor & transforming growth factor.

3.        Strong bacterio-, fungi- & viruostatic actions

4.        Inhibits inflammatory processes

5.        Improves circulation, oxygenation & nutrient supply of cells

6.        Improves blood viscosity & rheological properties of blood

7.        Decreases plasma cholesterol & low density lipoprotein, provokes activation of antioxidant protection

        system, therefore beneficial in cardiovascular ds.

8.        Destroys hepatitis A, B, non-A non-B virus, herpes virus, retrovirus.

9.        disinfectant activity

 

THERAPEUTIC USES OF OZONE THERAPY :-

                  DISORDERS                                                           UNDERLYING EFFECTS

1.      arterial circulatory disorders                                       activation of RBC

eg. Peripheral arterial ds, coronary artery                           metabolism, O2 release effect

ds, hypertension, cerebrovascular ds,

neurodegenerative ds.

 

2. external ulcers and skin lesions                                       disinfection,wound cleansing,

                                                                                            improve wound healing

 

3. pathological intestinal conditions                                    disinfection,immunoactivation,

  eg. Colitis, proctitis, fistulas                                              anti-inflammatory processes

 

4. infections                                                                        immunomodulation

  eg. Hepatitis, herpes simplex and zoster,

  generally weakened immune resistance

 

5. cancer and AIDS                                                            immunoactivation

 

6.  dysmetabolic syndrome eg. Diabetes,                           bioregulators

hyperlipidemia

 

7. geriatric conditions                                                         O2 release effect

                                                                                           immune- and enzymeactivation

 

8. rheumatic, autoimmune,inflammatory diseases               anti-inflammatory processes,

  eg.rheumatoid arthritis, psoriasis, multiple                        activation of antioxidative

  sclerosis, chronic fatigue syndrome,Parkinson                  capacity, immunomodulation

 

9. dentistry                                                                          disinfection, wound cleansing,

                                                                                           improve wound healing

 

10. hematologic diseases, pulmonary diseases                   improve viscosity and rheological properties

                                                                                           of blood, O2 release effect

 

REFERENCES :-

    1.  Bocci V.  Ozone: A new medical drug.  Springer, 2005.

    2.  Viebahn-Haensler R.  The use of ozone in medicine.  Karl F Haug Publishers, Heidelberg, 1999.

3.  Sweet F, Kao MS, Lee SCD.  Ozone selectively inhibits growth of human cancer cells.  Science 1980; 209:931-3.

4.  Madej P, Autoszeneski Z, Madej JA.  Ozonotherapy.  Materia Medica Polona 1995; 27:53-6.

5.  Garber GE et al.  The use of ozone-treated blood in the therapy of HIV infection and immune diseases :

        a pilot study of safety and efficacy.  AIDS 1991;5:981-4.

6.  Bocci V.  Autohemotherapy after treatment of blood with ozone.  J Intl Med Res 1994; 22:131-44.

7.  Hernandez F, Menendez S, Wong R.  Decrease of blood cholesterol and stimulation of antioxidative

         response in cardiopathy patients treated with endovenous ozone therapy.  Free Radical Biol & Med

         1995; 19:115-9.

8.  Vaughin JM et al.  Effects of ozone treatment on the infectivity of hepatitis A Virus.  Can J Microbiol

          1990; 36:557-60.

9.  Bocci V.  Ozone as a bioregulator.  Pharmacology and toxicology of Ozonotherapy today. 

          J Biol Regulators & Homeostatic agents 1996; 10:31-53.